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Calcium-activated potassium channel
Calcium-activated potassium channels are potassium channels gated by calcium, or are structurally or phylogenetically related to calcium gated channels. In humans they are divided into BK channels, IK channels, and SK channels based on their conductance (big, intermediate, and small conductance).
This family of ion channels is, for the most part, activated by intracellular Ca2+ and contains 8 members in the human genome. However, some of these channels (the KCa4 and KCa5 channels) are responsive instead to other intracellular ligands, such as Na+, Cl−, and pH. Furthermore, multiple members of family are both ligand and voltage activated, further complicating the description of this family. The KCa channel α subunits have six or seven transmembrane segments, similar to the KV channels but occasionally with an additional N-terminal transmembrane helix. The α subunits make homo- and hetero-tetrameric complexes. The calcium binding domain may be contained in the α subunit sequence, as in KCa1, or may be through an additional calcium binding protein such as calmodulin.
==Homology classification==
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